

In my distrobox bitwig set up with Wine 9.21 I am using the following with no issues
- Melda (various including MSoundFactory)
- Native instruments (including Reaktor and Massive X)
- unfiltered audio / plugin alliance including battalion
- psychic Modulation
- all arturia
- all Valhalla dsp
- Adam Szabo viper and jp6k
- lese smear And a bunch of others with no problems.
Usable with some issues
- Newfangled audio - plugins work and sound great but GUI hangs or is extremely laggy
Not working at all
- some eventide plugins
- all aberrant DSP
- all UVI
This is all under a unified wine prefix - o might try playing with different prefixes for different plugins and see if I can’t fix some of the above or some of the QoL issues
Check out the Fedora Atomic distros Silverblue, Kinoite, etc. You can just run arch in a distrobox for your arch needs while keeping a clean and stable core.