Fedora was one of the first to get rid of pulseaudio and replace it with Pipewire, so that shouldn’t be an issue.

Yeah, that’s definitely a concern. My first installation shredded its SD card in no time due to each request getting logged and stored on disk. Turning off long term query logging mitigated that issue, for my home network I don’t care about that history anyway.

Anybody got the feeling some games may be negatively affected by a PiHole ?

My RPi 2 has been happily running PiHole in my network for about 8 years now and with a number of pretty strict block lists, personally I never had any issues with games.